Prince Frederik of Luxembourg Passes Away at 22 After Battling Rare Genetic Condition
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Today, we bring heartbreaking news from the Luxembourg royal family. Prince Frederik of Nassau, the youngest son of Prince Robert of Luxembourg, has passed away at just 22 years old after a long and courageous battle with POLG mitochondrial disease. This rare genetic condition progressively robs the body’s cells of energy, leading to multiple organ failure over time. His passing marks a sorrowful moment for his family and those who admired his resilience.
Prince Frederik’s battle with POLG disease was one of immense strength and perseverance. Though he was born with the condition, it wasn’t until the age of 14 that he was officially diagnosed, when his symptoms became more pronounced. Despite his illness, he dedicated himself to raising awareness and helping others who faced similar challenges. He was the founder and creative director of the POLG Foundation, an organization committed to finding treatments and a cure for this devastating disease.
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His father, Prince Robert, shared the deeply emotional details of his son's final moments. On February 28, which was Rare Disease Day—a symbolic and poignant moment—Prince Frederik called in his loved ones to bid them farewell. One by one, he spoke to his parents, siblings, cousins, and close family members, sharing words of kindness, wisdom, and even humor in his final hours. His father described how, even in his last moments, Frederik’s humor and compassion shone through, as he left them all with a final family joke—a testament to his unwavering spirit and love for life.
The young prince’s passing was confirmed on March 1, and his family has since expressed profound sorrow while also celebrating his legacy. Prince Robert highlighted Frederik’s incredible strength, discipline, and kindness, stating that he was the ‘strongest person’ they had ever known. His passion for justice, fairness, and his deeply compassionate nature made him a remarkable individual who touched many lives.
Prince Frederik’s journey took him across different parts of the world. Born in Aix-en-Provence, France, he later lived in London, England, before settling in Switzerland in 2004. He received his education at prestigious institutions, including the International School in Geneva, Ecole Eden primary school, and St. George’s School in Clarens. Despite his health challenges, he remained dedicated to his studies, personal growth, and advocacy.
His passing comes at a time of significant transition within the Luxembourg royal family. His cousin, Grand Duke Henri, who reigned for 24 years, recently announced his abdication in favor of his son, Guillaume, who will officially assume the throne on October 3, 2025. This change in leadership, coupled with the loss of Prince Frederik, marks a deeply emotional period for the royal family and the nation.
Prince Frederik’s legacy will undoubtedly live on through the work of the POLG Foundation and the countless lives he touched. His family, friends, and supporters will remember him not only for his bravery in battling his illness but also for his kindness, wit, and unwavering commitment to making a difference. Luxembourg and the world mourn the loss of a young royal gone far too soon but celebrate the remarkable impact he made in his short yet meaningful life.
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