NFL Week 2 Fantasy Football Injury Report and Inactives Breakdown
It’s only Week 2 of the NFL season, but fantasy managers are already being hit with tough decisions as key injuries and inactives pile up. The Sunday slate features 13 games, and plenty of big names are either sidelined or expected to play through limited roles, which makes setting fantasy lineups a tricky challenge.
Let’s start with the quarterbacks. San Francisco will be without Brock Purdy, who is sidelined with both toe and shoulder injuries sustained in Week 1 against Seattle. That leaves Mac Jones stepping in under center against the Saints, but he won’t exactly be surrounded by his full arsenal. Brandon Aiyuk, George Kittle, and Demarcus Robinson are all unavailable, and Jauan Jennings remains a game-time decision. That means the 49ers’ passing game could look very different this week, with Ricky Pearsall and Kendrick Bourne expected to pick up the slack.
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Moving to running backs, Miami’s Jaylen Wright is doubtful with a knee issue. That likely means De’Von Achane carries most of the load again, with rookie Ollie Gordon II working in sparingly. Cleveland activated rookie Quinshon Judkins, who is expected to make his debut against Baltimore. Still, his workload may be closely managed, leaving Jerome Ford and Dylan Sampson in line for significant touches. Over in Philadelphia, Will Shipley has been ruled out with an oblique injury, so Tank Bigsby and AJ Dillon are expected to support Saquon Barkley against Kansas City.
Wide receivers are also being hit hard this week. Tampa Bay’s Chris Godwin is out with an ankle injury, which opens the door for rookie Emeka Egbuka to build on his impressive debut alongside Mike Evans. Kansas City’s Xavier Worthy, who suffered a shoulder dislocation in Week 1, has also been ruled out. That should push more targets to Marquise Brown, JuJu Smith-Schuster, and of course, Travis Kelce. Meanwhile, San Francisco’s Jennings is questionable, and Houston’s Christian Kirk won’t play, leaving rookies and depth options to step up.
Some defenders are missing as well, with names like Shaq Thompson of the Bills and DaRon Bland of the Cowboys sidelined, which could shift the outlook for opposing offenses and fantasy matchups.
For fantasy football managers, all of this means constant adjustments. If you were banking on Brock Purdy or Xavier Worthy, alternatives must be lined up. If you roster players like Emeka Egbuka or Ricky Pearsall, this could be a big opportunity to take advantage of expanded roles.
The NFL season is young, but Week 2 is already showing just how unpredictable the injury landscape can be. Staying updated and flexible with lineups is going to be crucial, because the difference between a win and a loss in fantasy often comes down to reacting faster than your competition when players go down.
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